Aims & Objectives
Aims
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Objectives
Objective One
The development of innovative food products to prevent undernutrition in Heart failure and Atrial Fibrillation older patients: a new chocolate AMBROSIA bar containing specific mix of probiotic strains and a cocktail of micro/macronutrients (fibers, protein hydrolysates, coenzyme Q10) and further studies on the metabolism and absorption of novel hydrolysates, involving the patient association. Realization of a proper-realistic strategy (in respect of the environment), from development and delivery of the AMBROSIA bar to the patients. The target population will be involved during the development of AMBROSIA bar
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Objective Two
Evaluation of the effects of “AMBROSIA” bar + nutritional consulting on undernutrition prevention and its impact on cognitive functioning and skeletal muscle mass of older patients through a prospective monocentric interventional clinical trial on biological samples-parallel group (RCT).
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Objective Three
Development of statistical and machine learning methods for identification of features from the “Microbiota-Inflammation-Brain axis” that are predictive for undernutrition and/or related to AMBROSIA bar treatment outcome and could be used as biomarkers for prevention and treatment of undernutrition.
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Work plans / Work packages
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Work package one
Research, development and delivery strategy of innovative “AMBROSIA” food product.
Task 1
Development of the AMBROSIA bar (P2. P3-duration: 8 months; timeline: months 1-8)
Task 2
In vitro digestion and macronutrient profiling and sequence characterization of peptides post in vitro digestion of commercial protein hydrolysates included in “AMBROSIA” food product
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Work package Two
Ambrosia” food strategy for preventing undernutrition and assessment of new biomarkers in older heart failure patients
Task 1
Ethics committee approval, selection of eligible patients, clinical assessment, sample collection, follow up
Task 2
Evaluation of “ambrosia bar in preventing undernutrition and skeletal muscle mass decline
Task 3
Evaluation of “ambrosia bar “effect on the functional, emotional and cognitive profile
Task 4
Measure of predictive biomarkers of undernutrition associated with the MicrobiotaInflammation-Brain axis
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Work package Three
Data harmonization and machine learning analyses
Task 1
Development of a semantic knowledgebase
Task 2
Development of Machine Learning methods for predicting undernutrition
Task 3
Development of statistical and ML methods for investigation of treatment effects
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Work package Four
AMBROSIA Coordination and Management
Task 1
Management plan
Task 2
Dissemination of the research results